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1

Structure and mechanism of inhibition of plant acetohydroxyacid synthase

Ronald G. Duggleby, Jennifer A. McCourt, Luke W. Guddat

Journal:

Plant Physiology and Biochemistry

Année:

2008

Langue:

english

Fichier:

PDF, 2.51 MB

english, 2008

2

Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel FeMn binuclear metal centre

Gerhard Schenk, Lyle E. Carrington, Mohsen Valizadeh, John de Jersey, Susan E. Hamilton, Luke W. Guddat

Journal:

Journal of Inorganic Biochemistry

Année:

2003

Langue:

english

Fichier:

PDF, 183 KB

english, 2003

3

Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase

Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P., Guddat, Luke W.

Journal:

Angewandte Chemie

Année:

2016

Langue:

english

Fichier:

PDF, 2.16 MB

english, 2016

4

Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families

Garcia, Mario D., Nouwens, Amanda, Lonhienne, Thierry G., Guddat, Luke W.

Journal:

Proceedings of the National Academy of Sciences

Année:

2017

Langue:

english

Fichier:

PDF, 2.11 MB

english, 2017

5

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W., McGeary, Ross P.

Journal:

European Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2018

6

Synthesis and evaluation of novel purple acid phosphatase inhibitors

Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W., McGeary, Ross P.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 2.67 MB

english, 2019

7

Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP , GMP and XMP

Terán, David, Doleželová, Eva, Keough, Dianne T., Hocková, Dana, Zíková, Alena, Guddat, Luke W.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 761 KB

english, 2019

8

Design and development of ((4-methoxyphenyl)carbamoyl) (5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl)amide analogues as Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors

Krishna, Vagolu Siva, Zheng, Shan, Rekha, Estharla Madhu, Nallangi, Radhika, Sai Prasad, D.V., George, Shilpa E., Guddat, Luke W., Sriram, Dharmarajan

Journal:

European Journal of Medicinal Chemistry

Année:

2020

Fichier:

PDF, 1.27 MB

2020

9

Structures of Mycobacterium tuberculosis Penicillin-Binding Protein 3 in Complex with Five Î² -Lactam Antibiotics Reveal Mechanism of Inactivation

Lu, Zuokun, Wang, Han, Zhang, Aili, Liu, Xiang, Zhou, Weihong, Yang, Cheng, Guddat, Luke, Yang, Haitao, Schofield, Christopher J., Rao, Zihe

Journal:

Molecular Pharmacology

Année:

2020

Fichier:

PDF, 1.12 MB

2020

10

Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-γ-interferon antibody

Zhao-chang Fan, Lin Shan, Benjamin Z. Goldsteen, Luke W. Guddat, Archana Thakur, Nicholas F. Landolfi, Man Sung Co, Maximiliano Vasquez, Cary Queen, Paul A. Ramsland, Allen B. Edmundson

Journal:

Journal of Molecular Recognition

Année:

1999

Langue:

english

Fichier:

PDF, 1.64 MB

english, 1999

11

Inhibition of purple acid phosphatase with α-alkoxynaphthylmethylphosphonic acids

Ross P. McGeary, Peter Vella, Jeffrey Y.W. Mak, Luke W. Guddat, Gerhard Schenk

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2009

Langue:

english

Fichier:

PDF, 450 KB

english, 2009

12

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine–guanine–xanthine phosphoribosyltransferase

Dana Hocková, Antonín Holý, Milena Masojídková, Dianne T. Keough, John de Jersey, Luke W. Guddat

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 710 KB

english, 2009

13

Systematic characterization of mutations in yeast acetohydroxyacid synthase : Interpretation of herbicide-resistance data

Ronald G. Duggleby, Siew Siew Pang, Hongqi Yu, Luke W. Guddat

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 490 KB

english, 2003

14

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

Gerhard Schenk, Tristan W Elliott, Eleanor Leung, Lyle E Carrington, Nataša Mitić, Lawrence R Gahan, Luke W Guddat

Journal:

BMC Structural Biology

Année:

2008

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2008

15

The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding

Luke W. Guddat, Jennifer L. Martin, James C.A. Bardwell, Thomas Zander

Journal:

Protein Science

Année:

1997

Langue:

english

Fichier:

PDF, 6.26 MB

english, 1997

16

Structural analysis of three His32 mutants of DsbA: Support for an electrostatic role of His32 in DsbA stability

Luke W. Guddat, James C. A. Bardwell, Rudi Glockshuber, Martina Huber-Wunderlich, Thomas Zander, Jennifer L. Martin

Journal:

Protein Science

Année:

1997

Langue:

english

Fichier:

PDF, 5.60 MB

english, 1997

17

Structure-activity relationships for a new family of sulfonylurea herbicides

Jian-Guo Wang, Zheng-Ming Li, Ning Ma, Bao-Lei Wang, Lin Jiang, Siew Siew Pang, Yu-Ting Lee, Luke W. Guddat, Ronald G. Duggleby

Journal:

Journal of Computer-Aided Molecular Design

Année:

2005

Langue:

english

Fichier:

PDF, 561 KB

english, 2005

18

The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment

John D. Orbell, Luke W. Guddat, Ken J. Machin, Neil W. Isaacs

Journal:

Analytical Biochemistry

Année:

1988

Langue:

english

Fichier:

PDF, 835 KB

english, 1988

19

Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site

Rajiv Tyagi, Yu-Ting Lee, Luke W. Guddat, Ronald G. Duggleby

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 181 KB

english, 2005

20

Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase

Jian-Guo Wang, Patrick K.-M. Lee, Yu-Hui Dong, Siew Siew Pang, Ronald G. Duggleby, Zheng-Ming Li, Luke W. Guddat

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 414 KB

english, 2009

21

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)

Emma-Karin I. Millers, Manuela Trabi, Paul P. Masci, Martin F. Lavin, John de Jersey, Luke W. Guddat

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 727 KB

english, 2009

22

Diverse binding site structures revealed in homology models of polyreactive immunoglobulins

Paul A. Ramsland, Luke W. Guddat, Allen B. Edmundson, Robert L. Raison

Journal:

Journal of Computer-Aided Molecular Design

Année:

1997

Langue:

english

Fichier:

PDF, 348 KB

english, 1997

23

The crystal structure of a bacterial Class II ketol-acid reductoisomerase: Domain conservation and evolution

Rajiv Tyagi, Stephane Duquerroy, Jorge Navaza, Luke W. Guddat, Ronald G. Duggleby

Journal:

Protein Science

Année:

2005

Langue:

english

Fichier:

PDF, 897 KB

english, 2005

24

The structure–activity relationship in herbicidal monosubstituted sulfonylureas

Zheng-Ming Li, Yi Ma, Luke Guddat, Pei-Quan Cheng, Jian-Guo Wang, Siew S Pang, Yu-Hui Dong, Cheng-Ming Lai, Ling-Xiu Wang, Guo-Feng Jia, Yong-Hong Li, Su-Hua Wang, Jie Liu, Wei-Guang Zhao, Bao-Lei Wan

Journal:

Pest Management Science

Année:

2012

Langue:

english

Fichier:

PDF, 720 KB

english, 2012

25

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine–guanine–(xanthine) phosphoribosyltransferases

Michal Česnek, Dana Hocková, Antonín Holý, Martin Dračínský, Ondřej Baszczyňski, John de Jersey, Dianne T. Keough, Luke W. Guddat

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 553 KB

english, 2012

26

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

Marcela Krečmerová, Martin Dračínský, Dana Hocková, Antonín Holý, Dianne T. Keough, Luke W. Guddat

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 533 KB

english, 2012

27

Penicillin inhibitors of purple acid phosphatase

Faridoon, Waleed M. Hussein, Nazar Ul Islam, Luke W. Guddat, Gerhard Schenk, Ross P. McGeary

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2012

28

Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter

Fernanda Ely, Marcelo M. Pedroso, Lawrence R. Gahan, David L. Ollis, Luke W. Guddat, Gerhard Schenk

Journal:

Journal of Inorganic Biochemistry

Année:

2012

Langue:

english

Fichier:

PDF, 657 KB

english, 2012

29

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy

Dianne T. Keough, Dana Hocková, Marcela Krečmerová, Michal Česnek, Antonín Holý, Lieve Naesens, Ian M. Brereton, Donald J. Winzor, John de Jersey, Luke W. Guddat

Journal:

Molecular and Biochemical Parasitology

Année:

2010

Langue:

english

Fichier:

PDF, 205 KB

english, 2010

30

Structure of CcmG/DsbE at 1.14 Å Resolution: High-Fidelity Reducing Activity in an Indiscriminately Oxidizing Environment

Melissa A Edeling, Luke W Guddat, Renata A Fabianek, Linda Thöny-Meyer, Jennifer L Martin

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 548 KB

english, 2002

31

The 1.1 å crystal structure of the neuronal acetylcholine receptor antagonist, α-conotoxin PnIA from Conus pennaceus

Shu-Hong Hu, John Gehrmann, Luke W Guddat, Paul F Alewood, David J Craik, Jennifer L Martin

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.37 MB

english, 1996

32

Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stabilization

Luke W Guddat, James CA Bardwell, Jennifer L Martin

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 701 KB

english, 1998

33

Crystal structure of mammalian purple acid phosphatase

Luke W Guddat, Alan S McAlpine, David Hume, Susan Hamilton, John de Jersey, Jennifer L Martin

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 289 KB

english, 1999

34

Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?

Kieran S Hadler, Thomas Huber, A Ian Cassady, Jane Weber, Jodie Robinson, Allan Burrows, Gregory Kelly, Luke W Guddat, David A Hume, Gerhard Schenk, Jack U Flanagan

Journal:

BMC Research Notes

Année:

2008

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2008

35

Synthesis of Novel N -Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

Hocková, Dana, Keough, Dianne T., Janeba, Zlatko, Wang, Tzu-Hsuan, de Jersey, John, Guddat, Luke W.

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2012

36

Crystal Structures of Intact IgG Antibodies

Allen B. Edmundson, Luke W. Guddat, Kim N. Andersen

Journal:

Année:

1993

Fichier:

PDF, 1.29 MB

1993

37

Local and Transmitted Conformational Changes on Complexation of an Anti-sweetener Fab

Luke W. Guddat, Lin Shan, Jerry M. Anchin, D.Scott Linthicum, Allen B. Edmundson

Journal:

Journal of Molecular Biology

Année:

1994

Fichier:

PDF, 2.24 MB

1994

38

The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins

Luke W. Guddat, Lin Shan, Christopher Broomell, Paul A. Ramsland, Zhao-chang Fan, Jerry M. Anchin, D.Scott Linthicum, Allen B. Edmundson

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 794 KB

english, 2000

39

Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors

Siew Siew Pang, Ronald G Duggleby, Luke W Guddat

Journal:

Journal of Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2002

40

Crystallographic Analysis of Antigen–Antibody Complexes: End-on Insertion of Ligands in Antibodies—CDR3 Loops as Arbiters

Allen B. Edmundson, Lin Shan, Zhao-chang Fan, Luke W. Guddat, B.Leif Hanson, Kim N. Andersen

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 482 KB

english, 1996

41

Three-dimensional structure of an Fv from a human IgM immunoglobulin

Zhao-chang Fan, Lin Shan, Luke W. Guddat, Xiao-min He, William R. Gray, Robert L. Raison, Allen B. Edmundson

Journal:

Journal of Molecular Biology

Année:

1992

Langue:

english

Fichier:

PDF, 17.10 MB

english, 1992

42

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Mohsen Valizadeh, Gerhard Schenk, Kevin Nash, Geoff W Oddie, Luke W Guddat, David A Hume, John de Jersey, Terrence R Burke Jr., Susan Hamilton

Journal:

Archives of Biochemistry and Biophysics

Année:

2004

Langue:

english

Fichier:

PDF, 291 KB

english, 2004

43

Plant collagenase: Unique collagenolytic activity of cysteine proteases from ginger

Misook Kim, Susan E. Hamilton, Luke W. Guddat, Christopher M. Overall

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

2007

Langue:

english

Fichier:

PDF, 1006 KB

english, 2007

44

The Crystal Structure of Free Human Hypoxanthine-guanine Phosphoribosyltransferase Reveals Extensive Conformational Plasticity Throughout the Catalytic Cycle

Dianne T. Keough, Ian M. Brereton, John de Jersey, Luke W. Guddat

Journal:

Journal of Molecular Biology

Année:

2005

Langue:

english

Fichier:

PDF, 803 KB

english, 2005

45

Conformational Changes in a Plant Ketol-Acid Reductoisomerase upon Mg2+ and NADPH Binding as Revealed by Two Crystal Structures

Eleanor W.W. Leung, Luke W. Guddat

Journal:

Journal of Molecular Biology

Année:

2009

Langue:

english

Fichier:

PDF, 3.15 MB

english, 2009

46

An unusual human IgM antibody with a protruding HCDR3 and high avidity for its peptide ligands

Paul A. Ramsland, Lin Shan, Carolyn R. Moomaw, Clive A. Slaughter, Zhao-Chang Fan, Luke W. Guddat, Allen B. Edmundson

Journal:

Molecular Immunology

Année:

2000

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2000

47

Three-dimensional structure of a human Fab with high affinity for tetanus toxoid

Catherine Faber, Lin Shan, Zhao-chang Fan, Luke W Guddat, Christina Furebring, Mats Ohlin, Carl A.K Borrebaeck, Allen B Edmundson

Journal:

Immunotechnology

Année:

1998

Langue:

english

Fichier:

PDF, 963 KB

english, 1998

48

Identification of Purple Acid Phosphatase Inhibitors by Fragment-Based Screening: Promising New Leads for Osteoporosis Therapeutics

Daniel Feder, Waleed M. Hussein, Daniel J. Clayton, Meng-Wei Kan, Gerhard Schenk, Ross P. McGeary, Luke W. Guddat

Journal:

Chemical Biology & Drug Design

Année:

2012

Langue:

english

Fichier:

PDF, 684 KB

english, 2012

49

Bacterial and Plant Ketol-Acid Reductoisomerases Have Different Mechanisms of Induced Fit during the Catalytic Cycle

Sze-Ho Wong, Thierry G.A. Lonhienne, Donald J. Winzor, Gerhard Schenk, Luke W. Guddat

Journal:

Journal of Molecular Biology

Année:

2012

Langue:

english

Fichier:

PDF, 1.95 MB

english, 2012

50

Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase

Luke W. Guddat, Siska Vos, Jennifer L. Martin, Dianne T. Keough, John de Jersey

Journal:

Protein Science

Année:

2002

Langue:

english

Fichier:

PDF, 438 KB

english, 2002